Expanded primary cells
 
Human Keratinocytes

Human Keratinocytes

Human keratinocytes are the predominant cell population of the epidermis and are central to epidermal homeostasis, barrier formation, innate immune responses, and wound re-epithelialization. Primary human keratinocytes isolated from skin provide an in vitro model for investigating keratinocyte proliferation, differentiation, inflammatory signaling, epidermal barrier biology, and cutaneous disease mechanisms.

During differentiation, basal keratinocytes characteristically express KRT5/K5 and KRT14/K14, whereas suprabasal differentiation is associated with KRT1/K1 and KRT10/K10, followed by increased expression of differentiation and cornification markers such as involucrin, transglutaminase 1, and filaggrin. Calcium-induced differentiation and 3D air–liquid-interface culture can be used to investigate keratinocyte differentiation, epidermal stratification, and barrier formation.

Key Features

  • Primary human epidermal keratinocytes for skin and keratinocyte research.

  • Models of keratinocyte proliferation, differentiation, and epidermal stratification.

  • Suitable for molecular, cellular, and functional assays.

  • Relevant for investigating inflammatory and epidermal barrier responses.

Usual Research Applications

  • Epidermal differentiation and skin barrier studies.

  • Wound healing and re-epithelialization research.

  • Dermatological disease and inflammatory signaling studies.

  • 2D keratinocyte cultures and 3D epidermal or human skin-equivalent models.

  • Gene expression, immunofluorescence, and drug-response studies.

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Yes, upcyte distributes several product references in the keratinocytes category, sourced from specialist suppliers. Depending on the product family, references may vary in terms of format, packaging, brand, supplier, technical specifications or availability.

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Cat#
Description
Cond.
Price Bef. VAT
CKE002
upcyte® Keratinocytes-expanded primary cells
 2millioncells/vial 
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