Upcyte Publications

Publications Featuring upcyte® Cells

upcyte presents a selection of peer-reviewed publications utilizing upcyte® technology in areas such as hepatotoxicity evaluation, drug metabolism studies, cholestasis mechanisms, and advanced liver model development. These studies demonstrate the value, consistency, and translational relevance of expandable human hepatocytes and related cell systems.

Selected Publications

2023

Kaden et al. – Generation & characterization of expandable human liver sinusoidal endothelial cells and their application to assess hepatotoxicity in an advanced in vitro liver model

Dynamic42 GmbH, Jena, Germany
Upcyte technologies GmbH - upcyte Group, Hamburg, Germany

2022

Romaldini et al. – Sub-Lethal Concentrations of Graphene Oxide Trigger Acute-Phase Response and Impairment of Phase-I Xenobiotic Metabolism in Upcyte® Hepatocytes

D3 PharmaChemistry, Istituto Italiano di Tecnologia, Genoa, Italy; Electron Microscopy Facility, Istituto Italiano di Tecnologia, Genoa, Italy; Unit of Molecular Oncology and Angiogenesis, IRCCS Ospedale Policlinico San Martino, Genoa, Italy

2020

Korn et al. – Comparison of metabolic and mitogenic response in vitro of the rapid-acting insulin lispro product SAR342434, and US- and EU-approved Humalog

Sanofi-Aventis (Frankfurt, Germany)

Petrov et al. – Epistane, an anabolic steroid used for recreational purposes, causes cholestasis with elevated levels of cholic acid conjugates, by upregulating bile acid synthesis (CYP8B1) and cross-talking with nuclear receptors in human hepatocytes

Instituto de Investigación Sanitaria La Fe (IIS La Fe, Valencia, Spain)

López-Riera et al. – A novel microRNA signature for cholestatic drugs in human hepatocytes and its translation into novel circulating biomarkers for drug-induced liver injury patients

Instituto de Investigación Sanitaria La Fe (IIS La Fe, Valencia, Spain)

Martínez-Sena et al. – The Vitamin D Receptor Regulates Glycerolipid and Phospholipid Metabolism in Human Hepatocytes

Instituto de Investigación Sanitaria La Fe (IIS La Fe, Valencia, Spain)

2019

Nischalke et al. – The PNPLA3 I148M variant promotes lipid-induced hepatocyte secretion of CXC chemokines establishing a tumorigenic milieu

University Hospital of Bonn (Bonn, Germany)

Tolosa et al. – Long-term and mechanistic evaluation of drug-induced liver injury in Upcyte human hepatocytes

Instituto de Investigación Sanitaria La Fe (IIS La Fe, Valencia, Spain)

Schulz et al. – NADPH-cytochrome P450 reductase expression and enzymatic activity in primary-like human hepatocytes and HepG2 cells for in vitro biotransformation studies

Brandenburg University of Technology Cottbus-Senftenberg (Senftenberg, Germany)

2018

Fernández-Murga et al. – Advances in drug-induced cholestasis: Clinical perspectives, potential mechanisms and in vitro systems

Instituto de Investigación Sanitaria La Fe (IIS La Fe, Valencia, Spain)

Petrov et al. – Predicting drug-induced cholestasis: preclinical models

Instituto de Investigación Sanitaria La Fe (IIS La Fe, Valencia, Spain)

Schaefer et al. – Quantitative Expression of Hepatobiliary Transporters and Functional Uptake of Substrates in Hepatic Two-Dimensional Sandwich Cultures: A Comparative Evaluation of Upcyte and Primary Human Hepatocytes

Boehringer Ingelheim (Biberach, Germany & Kobe, Japan)

Gaitantzi et al. – Di (2-Ethylhexyl) Phthalate and Its Role in Developing Cholestasis: An In Vitro Study on Different Liver Cell Types

Department of Medicine II, Medical Faculty Mannheim, Heidelberg University (Mannheim, Germany)

2017

Johaennig et al. – The formation of estrogen-like tamoxifen metabolites and their influence on enzyme activity and gene expression of ADME genes

Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology & University of Tuebingen (Tuebingen & Stuttgart, Germany)

2016

Rolvering et al. – Crosstalk between different family members: IL27 recapitulates IFNγ responses in HCC cells, but is inhibited by IL6-type cytokines

University of Luxembourg (Belvaux, Luxembourg)

Tolosa et al. – human upcyte hepatocytes: characterization of the hepatic phenotype and evaluation for acute and long term hepatotoxicity routine testing

University of Valencia (Valencia, Spain)

Schaefer et al. – upcyte human hepatocytes: a potent in vitro tool for the prediction of hepatic clearance of metabolically stable compounds

Boehringer Ingelheim (Biberach, Germany)

2015

Levy et al. – Long-term culture and expansion of primary human hepatocytes – Nature Biotech

The Hebrew University of Jerusalem (Israel)

Ramachandran et al. – in vitro generation of functional liver organoid-like structures using adult human cells

University of Heidelberg/Mannheim & Wuerzburg (Germany), University of Tromso (Norway)

Deuschle et al. – the nuclear bile acid receptor FXR controls the liver derived tumor suppressor histidine-rich glycoprotein

Phenex Pharmaceuticals AG (Heidelberg, Germany) // Synovo GmbH (Tuebingen, Germany)

Ramachandran et al. – applicability of second-generation upcyte® human hepatocytes for use in CYP inhibition and induction studies

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