Korn et al.,– Comparison of metabolic and mitogenic response in vitro of the rapid-acting insulin lispro product SAR342434, and US- and EU-approved Humaloglink

Sanofi-Aventis (Frankfurt, Germany)

Petrov et al.,-Epistane, an anabolic steroid used for recreational purposes, causes cholestasis with elevated levels of cholic acid conjugates, by upregulating bile acid synthesis (CYP8B1) and cross‑talking with nuclear receptors in human hepatocyteslink

Instituto de Investigación Sanitaria La Fe (IIS La Fe, Valencia, Spain)

López-Riera et al.,– A novel microRNA signature for cholestatic drugs in human hepatocytes and its translation into novel circulating biomarkers for drug-induced liver injury patients. link

Instituto de Investigación Sanitaria La Fe (IIS La Fe, Valencia, Spain)

Martínez-Sena et al.,-The Vitamin D Receptor Regulates Glycerolipid and Phospholipid Metabolism in Human

Instituto de Investigación Sanitaria La Fe (IIS La Fe, Valencia, Spain)


Nischalke et al.,– The PNPLA3 I148M variant promotes lipid-induced hepatocyte secretion of CXC chemokines establishing a tumorigenic

University Hospital of Bonn (Bonn, Germany)

Tolosa et al.,-Long-term and mechanistic evaluation of drug-induced liver injury in Upcyte human hepatocytes. link

Instituto de Investigación Sanitaria La Fe (IIS La Fe, Valencia, Spain)

Schulz et al.,– NADPH-cytochrome P450 reductase expression and enzymatic activity in primary-like human hepatocytes and HepG2 cells for in vitro biotransformation studies. link

Brandenburg University of Technology Cottbus-Senftenberg (Senftenberg, Germany)


Fernández-Murga et al.,– Advances in drug-induced cholestasis: Clinical perspectives, potential mechanisms and in vitro systems. link

Instituto de Investigación Sanitaria La Fe (IIS La Fe, Valencia, Spain)

Petrov et al.,– Predicting drug-induced cholestasis: preclinical models. link

Instituto de Investigación Sanitaria La Fe (IIS La Fe, Valencia, Spain)

Schaefer et al.,– Quantitative Expression of Hepatobiliary Transporters and Functional Uptake of Substrates in Hepatic Two-Dimensional Sandwich Cultures: A Comparative Evaluation of Upcyte and Primary Human Hepatocytes. link

Boehringer Ingelheim (Biberach, Germany & Kobe, Japan)

Gaitantzi et al.,– Di (2-Ethylhexyl) Phthalate and Its Role in Developing Cholestasis: An In Vitro Study on Different Liver Cell Types link

Department of Medicine II, Medical Faculty Mannheim, Heidelberg University (Mannheim, Germany)


Johaennig et al.,– The formation of estrogen-like tamoxifen metabolites and their influence on enzyme activity and gene expression of ADME genes. link

Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology & University of Tuebingen (Tuebingen & Stuttgart, Germany)


Rolvering et al.,– Crosstalk between different family members: IL27 recapitulates IFNγ responses in HCC cells, but is inhibited by IL6-type cytokines link (open access)

University of Luxembourg (Belvaux, Luxembourg)

Tolosa et al.,– human upcyte hepatocytes: characterization of the hepatic phenotype and evaluation for acute and long term hepatotoxicty routine testing link

University of Valencia (Valenica, Spain)

Schaefer et al.,– upcyte human hepatocytes: a potent in vitro tool for the prediction of hepatic clearance of metabolically stable compounds link

Boehringer Ingelheim (Biberach, Germany)


Levy et al.,– Long-term culture and expansion of primary human hepatocytes – Nature Biotechlink

The Hebrew University of Jerusalem (Israel)

Ramachandran et al.,– in vitro generation of functional liver organoid-like structures using adult human cells. link

University of Heidelberg/Mannheim & Wuerzburg (Germany), University of Tromso (Norway)

Deuschle et al., – the nuclear bile acid receptor FXR controls the liver derived tumor suppressor histidine-rich glycoprotein. link

Phenex Pharmaceuticals AG (Heidelberg, Germany) // Synovo GmbH (Tuebingen, Germany)

Ramachandran et al., – applicability of second-generation upcyte® human hepatocytes for use in CYP inhibition and induction studieslink

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