The skin is the largest organ of the human body and represents our first line of defense against external factors. Its diverse functions include the protection from pathogens, thermal insulation, temperature regulation, as well as sensation and wound healing. This functional diversity is achieved by a complex interplay between different cell types present in different skin layers. Located above the dermis (connective tissue) and the hypodermis (subcutaneous tissue), the epidermis forms the outermost layer of the skin and maintains homeostasis against physical, chemical and biological stresses.
Keratinocytes represent the main cell type found in the epidermis and are thus attractive tools for studying wound healing and stress responses, as well as sensitizing properties and overall toxicity of test compounds. To increase your throughput, we offer standardized, ready-to-use upcyte® Human Epidermal Keratinocytes isolated from juvenile donor material.