The endothelial cells lining blood vessels of the skin share features of endothelial cells elsewhere in the body, but they also exhibit several skin specific characteristics. These include wound healing, control of hemostasis, temperature regulation, and the modulation of inflammation.
upcyte® mvECs from upcyte technologies are isolated from human dermal microvascular vessels and exhibit an extended proliferation capacity up to 35 population doublings compared to primary cells. It is recommended to use Endothelial Cell Culture Medium for the optimized culturing of upcyte® and also primary mvECs.
The cells are tested positive for CD31, Von Willebrand factor (VWF) as well tube formation in matrigel.
For each product a protocol for use and a certificate of analysis will be delivered. All cells have been tested for the absence of CMV, HIV, Hepatitis B and C and microbial contaminants (fungi, bacteria and mycoplasma). upcyte® cells are genetically modified cells (GMO, genetically modified organism) classified as risk group 1 and have to be handled in a genetic engineering facility carrying out genetic engineering work at Security Level 1 (e.g. S1 lab). upcyte®Hepatocytes and upcyte® Endothelial Cells are officially classified as risk group 1 organisms by the German Federal Office of Consumer Protection and Food Safety (BVL) and the Central Committee on Biological Safety (ZKBS). For further information please use the following link and enter “upcyte” in the search box.