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upcyte® Hepatocyte for Cytotox

There is an increasing demand to develop more predictive models for liver toxicity due to the high attrition rate of drugs causing liver damage once they enter the market. Immortalized hepatic cell lines are often used for cytotoxicity screening since they grow continuously, are easily available, and can be standardized across laboratories. However, cell lines tend to have low or lacking phase 1 and 2 activities and/or transporter functions and this can lead to false negative results when assessing drug toxicity.

cytotox kit graph

Graph 1: A comparison of the IC50 values generated in upcyte® hepatocytes from Donor 422A and Donor 10 (using MTS) with those cited in the literature for primary hepatocytes (using MTT).

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