Schaefer et al.,- Quantitative Expression of Hepatobiliary Transporters and Functional Uptake of Substrates in Hepatic Two-Dimensional Sandwich Cultures: A Comparative Evaluation of Upcyte and Primary Human Hepatocytes.
Boehringer Ingelheim (Biberach, Germany & Kobe, Japan)
Gaitantzi et al.,- Di (2-Ethylhexyl) Phthalate and Its Role in Developing Cholestasis: An In Vitro Study on Different Liver Cell Types
Department of Medicine II, Medical Faculty Mannheim, Heidelberg University (Mannheim, Germany)
Johaennig et al.,- The formation of estrogen-like tamoxifen metabolites and their influence on enzyme activity and gene expression of ADME genes.
Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology & University of Tuebingen (Tuebingen & Stuttgart, Germany)
Rolvering et al.,- Crosstalk between different family members: IL27 recapitulates IFNγ responses in HCC cells, but is inhibited by IL6-type cytokines (open access)
University of Luxembourg (Belvaux, Luxembourg)
Tolosa et al.,- human upcyte hepatocytes: characterization of the hepatic phenotype and evaluation for acute and long term hepatotoxicty routine testing
University of Valencia (Valenica, Spain)
Schaefer et al.,- upcyte human hepatocytes: a potent in vitro tool for the prediction of hepatic clearance of metabolically stable compounds
Boehringer Ingelheim (Biberach, Germany)
Oct, 2015 Nature Biotech
Levy et al.,- Long-term culture and expansion of primary human hepatocytes
The Hebrew University of Jerusalem (Israel)
Ramachandran et al.,- in vitro generation of functional liver organoid-like structures using adult human cells.
University of Heidelberg/Mannheim & Wuerzburg (Germany), University of Tromso (Norway)
Deuschle et al., - the nuclear bile acid receptor FXR controls the liver derived tumor suppressor histidine-rich glycoprotein.
Phenex Pharmaceuticals AG (Heidelberg, Germany) // Synovo GmbH (Tuebingen, Germany)
Ramachandran et al., - applicability of second-generation upcyte® human hepatocytes for use in CYP inhibition and induction studies
Noerenberg et al., - optimization of upcyte® human hepatocytes for the in vitromicronucleus assay
Scheller et al., - upcyte® microvascular endothelial cells repopulate decellularized scaffold.
Burkhard et al., - Generation of proliferating human hepatocytes using upcyte® technology: characterisation and applications in induction and cytotoxicity assays (1st generation upcyte hepatocytes)
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