upcyte head welcome

Feb, 2019

López-Riera et al.,- A novel microRNA signature for cholestatic drugs in human hepatocytes and its translation into novel circulating biomarkers for drug-induced liver injury patients. link

Instituto de Investigación Sanitaria La Fe (IIS La Fe, Valencia, Spain)

Tolosa et al.,-Long-term and mechanistic evaluation of drug-induced liver injury in Upcyte human hepatocytes. link

Instituto de Investigación Sanitaria La Fe (IIS La Fe, Valencia, Spain)

July, 2018

Fernández-Murga et al.,- Advances in drug-induced cholestasis: Clinical perspectives, potential mechanisms and in vitro systems. link

Instituto de Investigación Sanitaria La Fe (IIS La Fe, Valencia, Spain)

June, 2018

Petrov et al.,- Predicting drug-induced cholestasis: preclinical models. link

Instituto de Investigación Sanitaria La Fe (IIS La Fe, Valencia, Spain)

Feb, 2018

Schaefer et al.,- Quantitative Expression of Hepatobiliary Transporters and Functional Uptake of Substrates in Hepatic Two-Dimensional Sandwich Cultures: A Comparative Evaluation of Upcyte and Primary Human Hepatocytes. link

Boehringer Ingelheim (Biberach, Germany & Kobe, Japan)

Feb, 2018

Gaitantzi et al.,- Di (2-Ethylhexyl) Phthalate and Its Role in Developing Cholestasis: An In Vitro Study on Different Liver Cell Types link

Department of Medicine II, Medical Faculty Mannheim, Heidelberg University (Mannheim, Germany)

Dec, 2017

Johaennig et al.,- The formation of estrogen-like tamoxifen metabolites and their influence on enzyme activity and gene expression of ADME genes. link

Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology & University of Tuebingen (Tuebingen & Stuttgart, Germany)

Dec, 2016

Rolvering et al.,- Crosstalk between different family members: IL27 recapitulates IFNγ responses in HCC cells, but is inhibited by IL6-type cytokines link (open access)

University of Luxembourg (Belvaux, Luxembourg)

May, 2016

Tolosa et al.,- human upcyte hepatocytes: characterization of the hepatic phenotype and evaluation for acute and long term hepatotoxicty routine testing link

University of Valencia (Valenica, Spain)

March, 2016

Schaefer et al.,- upcyte human hepatocytes: a potent in vitro tool for the prediction of hepatic clearance of metabolically stable compounds link

Boehringer Ingelheim (Biberach, Germany)

Oct, 2015 Nature Biotech

Levy et al.,- Long-term culture and expansion of primary human hepatocytes link

The Hebrew University of Jerusalem (Israel)

Oct, 2015

Ramachandran et al.,- in vitro generation of functional liver organoid-like structures using adult human cells. link

University of Heidelberg/Mannheim & Wuerzburg (Germany), University of Tromso (Norway)

June, 2015

Deuschle et al., - the nuclear bile acid receptor FXR controls the liver derived tumor suppressor histidine-rich glycoprotein. link

Phenex Pharmaceuticals AG (Heidelberg, Germany) // Synovo GmbH (Tuebingen, Germany)

June, 2015

Ramachandran et al., - applicability of second-generation upcyte® human hepatocytes for use in CYP inhibition and induction studies link

Dec, 2013

Noerenberg et al., - optimization of upcyte® human hepatocytes for the in vitromicronucleus assay link

Jan, 2013

Scheller et al., - upcyte® microvascular endothelial cells repopulate decellularized scaffold. link

Oct, 2012

Burkhard et al., - Generation of proliferating human hepatocytes using upcyte® technology: characterisation and applications in induction and cytotoxicity assays (1st generation upcyte hepatocytes)link



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